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Welcome to ChemJam! A medicinal chemistry blog with a bad name but great topics!

My name is John Widen, a medicinal chemist. I have >5 years of experience in biotech working on small molecule programs in oncology and neurodegeneration. I thought the world could use one more blog. I'm going to focus on aspects of drug discovery from a medicinal chemistry prespective. I'm planning to cover topics such as medicinal chemistry experiences, patent literature, and maybe some hot gossip. Because we all know chemists love gossip. Don't worry, I am a person of integrity and would never divulge any confidential information. Please forgive me if parts of the website do not work properly. I am learning HTML, CSS, etc. on the fly and will hopefully have the website optimized soon. If you have any ideas on what you'd like to read about or have any feedback please email me at jwiden@chemjam.com. Thanks for stopping by.

My First Article! Allow me to introduce myself

By John Widen • July 14, 2025

Tags: Introduction • First Article • Personal

Welcome to my first ever blog post! I know the name ChemJam might seem like a terrible choice to many people, but the domain name was supremely cheap, and I currently don’t have a consistent income right now (Hire me!). So, you will just have to deal with it...

APOE4 increases inflammation related pathways

By John Widen • July 18, 2025

Tags: Publication • Commentary Perspective • ApoE • Alzheimer's Disease • Parkinson's Disease • Dementia

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Patent Busting A Literature-based Approach

By John Widen • July 19th, 2025

Tags: Medicinal Chemistry • Patents • Literature-based Approach • Information-driven Approach • How To

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The case for CD47 small molecule inhibition

By John Widen • TBD

Tags: CD47 • Cardivascular Disease • Cancer • Check-point inhibitors • Immunity • PD-1 • PD-L1 • SIRPalpha

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